نوع مقاله : فیزیولوژی (جانوری)
نویسندگان
1 بخش فیزیولوژی، دانشکده کشاورزی و منابع طبیعی مغان، دانشگاه محقق اردبیلی، اردبیل، ایران
2 گروه علوم دامی، دانشکده کشاورزی و منابع طبیعی مغان، دانشگاه محقق اردبیلی، اردبیل، ایران
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Barberry fruit (Berberis vulgaris L.) has been introduced in Iranian traditional medicine as a pain reliever. The aim of this study was to investigate the interaction of the histaminergic system and aqueous extract of Barberry on formalin-induced pain in rats. In this experimental study, 48 male Wistar rats weighing 220-250 g, were divided into in 8 groups with 6 rats in each groups: control group (normal saline + 1% formalin intraplantar injection), 3 treatment group with aqueous extract of barberry (75, 150 and 300 mg/kg), treatment group with pyrilamine, H1 receptor antagonist (10 mg/kg) alone, pretreatment group with pyrilamine (10 mg/kg) + aqueous extract of barberry (300 mg/kg), Treatment group with famotidine, H2 receptor antagonist (20 mg/kg) alone, pretreatment group with famotidine (20 mg/kg) + aqueous extract of barberry (300 mg/kg). Pain was evaluated by formalin test. Data analysis was performed using one-way ANOVA and then Duncan's test. Intraperitoneal injection of aqueous extract of barberry significantly reduced the pain response in the second phase of formalin pain (p <0.05). Pre-treatment of pyrilamin and famotidine and then aqueous extract of barberry improved the analgesic response of the aqueous extract of barberry in the second phase of formalin pain (p <0.05). The results of this study indicated that the aqueous extract of barberry may have analgesic effects by potentiating the pain relief potentials by histamine antagonists, especially the H1 receptor antagonist.
کلیدواژهها [English]