Clinical and biochemical study of the effect of Cuminum cyminum Linn. (cumin) on the healing of skin wound

Abstract

Introduction: Wound healing and the use of medicinal plants are important and vital issues. Herbal medicines, including black cumin, have been used due to their effectiveness in treating wounds and minimal side effects. Therefore, in this research, the effect of green cumin, because it is from the cumin family and is native to Iran, on the rate of healing in terms of appearance and the amount of tissue protein in skin wounds was investigated. Materials and Methods: Twenty-five male rats were randomly divided into 5 groups of 5, negative control, placebo group (gel and no cumin extract), nitrofurazone ointment group, 10% cumin extract group and 20% cumin extract group. They were randomly divided .
After the preparation and sterile conditions, a full-thickness skin wound was created on the back of the rats. The wounds were treated for 10 days. Results: The results showed that in cumin groups 10 and 20%, wounds heal better and faster on the 10th day after wound formation. In terms of the amount of wound protein, the amount of tissue protein was higher in cumin groups, but there was a significant difference between the groups. Conclusion: The results showed that cumin extract, unlike black cumin extract, despite the faster and better healing of wounds in terms of appearance, does not have a significant effect on the amount of skin protein.